Congratulations to my long-time colleagues Michael and Jorge from University of Puerto Rico. Excellent work. RECNAC II!
Book available here: http://www.springer.com/biomed/cancer/book/978-1-4939-1889-8
A comprehensive collection on IVC Literature and Therapies
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199254/
Conclusions: Due to the debilitating nature of cancer- and chemotherapy-related fatigue and other side-effects that impact on QOL, any therapy that can alleviate these symptoms will significantly improve the QOL of sufferers. A number of phase I clinical trials have shown that high-dose IV vitamin is safe and well tolerated in cancer patients, either as a monotherapy (8, 45) or in combination with other chemotherapeutic agents (28, 46). Although direct anti-cancer effects of IV vitamin C have not yet been confirmed by these small studies, there is consistent evidence that IV vitamin C can improve cancer patient’s QOL (6–9) and decrease multiple aspects of fatigue (22, 23). Patients with cancer-related fatigue are often prescribed central nervous system stimulants, despite a limited evidence base, and the fact that these are often ineffective (50). Thus, if future intervention studies indicate that IV vitamin C is an effective anti-fatigue therapy, this will reduce the use of ineffective medications and their accompanying side-effects. Overall, additional well-designed placebo-controlled studies investigating the effects of IV vitamin C on QOL of cancer patients appear warranted.
New article out of New Zealand
Carr, Vissers, and Cook
Fatigue is a common, often debilitating, side effect of cancer chemotherapy.
Pharmacologic vitamin C has been used as an alternative treatment for the disease
itself but its effects on fatigue have not often been documented. Here we report on the
case of a woman with recurrent breast cancer, undergoing weekly chemotherapy, with
lethargy as a major symptom. Vitamin C (50 g/session) was administered twice
weekly and quality of life and multidimensional fatigue symptomology questionnaires
were undertaken. Dramatic decreases in fatigue and insomnia were observed, as well
as increased cognitive functioning. There were no adverse side effects of i.v. vitamin
C.
Nature, BBC, NBC. Our paper that first showed that cancer-killing vitamin C levels could be achieved in people:
Med Hypotheses. 1995 Mar;44(3):207-13.http://www.ncbi.nlm.nih.gov/pubmed/7609676
Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent.
Riordan NH, Riordan HD, Meng X, Li Y, Jackson JA.
http://www.nature.com/news/vitamin-c-injections-ease-ovarian-cancer-treatments-1.14673
http://www.nbcnews.com/health/cancer/vitamin-c-may-help-cancer-treatment-study-finds-n23066
This spreadsheet was created by Dr. Joseph Casciari, a dear friend and genius collaborator. It allows for the prediction of plasma levels of ascorbate. Input dose, duration, volume, patient height and weight.Vitamin C Pharmacokinetic Curves
Ph.D. Dissertation NHRDissertationFinal
This website is dedicated to the science of the effects of vitamin C on malignancies and people with malignant diseases.
My father, Hugh Riordan, had a patient in the early 1980’s come to his clinic requesting intravenous vitamin C. The patient, a 70-year-old man (I’ll refer to him as “Sam”) was recently diagnosed with renal (kidney) cell carcinoma. The cancer had spread to his lungs. His oncologist had told him there were no treatments available to him. Sam had read about the work of Linus Pauling and Ewen Cameron–Link: Prolongation survival Pauling. In the so-called Vale of Leven trial, 100 terminal cancer patients were given 10 grams of vitamin C per day. The people receiving the vitamin C lived an average of 300 days longer than 1000 matched controls (people receiving the same treatment without the vitamin C). 22% of the treated patients were alive 1 year after being deemed “untreatable” versus 0.4% of the controls.
Dr. Hugh, as my father was known, was known to be the only doctor in Wichita, Kansas who gave vitamin C through the vein (intravenously). Sam was given 30 grams of vitamin C intravenously (IVC) twice per week. A copy of the journal article can be found here. 5 months later no evidence of cancer could be found. This paper was written 3.5 years after he started the IVC treatments and at that time no evidence of cancer could be found. A subsequent paper about another patient referred to Sam and stated he died cancer free of congestive heart failure 12 years after starting treatment.